Leptin and fractalkine: Novel subcutaneous cytokines in burn injury

Burn injury in Mottahari Burn Center in Tehran, Iran

Synovial fractalkine plays important role in cytokines’ related knee edema variation in rat arthritis model

Introduction: The systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. This study was purposed to verify the roles of synovial TNF-α, IL-6 and fractalkine (Fkn) in edema changes during different stages of Complete Freund’s Adjuvant (CFA)-induced knee arthritis in rats. Methods: 168 male Wistar rats were divided i...

Inflammatory Cytokines and Their Prognostic Ability in Cases of Major Burn Injury

BACKGROUND Major burn injuries induce inflammatory responses and changes in the levels of various cytokines. This study was conducted to assess early changes in the serum levels of inflammatory cytokines after burn injury, identify cytokines associated with mortality, and characterize correlations among cytokines. METHODS Blood samples of 67 burn patients were collected on days 1 and 3 after ...

Fractalkine: a novel cardiac chemokine?

The endothelium plays a central role in maintaining cardiovascular integrity, function, and the response to injury. A multitude of bioactive molecules is known to be expressed in and secreted from the endothelium under both physiological and pathophysiological circumstances. Xuan et al. uncover a unique role for fractalkine (FKN), a novel membrane-bound chemokine that is mainly expressed in end...

Morphological Changes in Subcutaneous White Adipose Tissue After Severe Burn Injury.

Severe burn injury produces a plethora of metabolic abnormalities which contribute to the prolonged morbidity of burn survivors. The authors have recently demonstrated trans-differentiation of white adipose tissue (WAT) after burn trauma, toward a more thermogenic phenotype. However, the impact of burn injury on subcutaneous WAT (sWAT) morphology in humans is unknown. Here, the authors studied ...